Regional CDL Driver Jobs in South Carolina May 2026

Indian River Transport Co

East Central Regional CDL-A Truck Driver | 60 CPM

Hiring in South Carolina and 46 other locations
Regional
2 weeks out
$0.60 Per mile

$0.60 Cpm - Loaded & Empty. +.05 CPM for HazMat. $200 Monthly Safety Bonus. $20/hr. Detention Pay.
Home every 2 weeks. No Tanker Experience Required. Extra Pay for Loads < 250 miles. Rider Policies.
Paid Orientation. Medical, Dental & Vision. 401(K) with Company Match. Clean Inspection Bonus

Eos Inc.

CDL-A Lease Purchase | $0 Down, No Credit Check

Hiring in South Carolina and 46 other locations
OTR, Regional
2 weeks out
$2,200 - 2,500 Per week

Gross pay: $6,000-$8,000 weekly. Earn approx. $2,200-$2,500 weekly (after all lease cost). Lease Purchase Pay: 73% of revenue. Paid 2-day Orientation
$0 Down, No Credit Check. Home every 2 weeks.Truck Payments: typically range from $650-$1,040/week. Inspection and referral bonuses.
Lease Op Charges fixed cost: $475/week total. Pet & Rider policies. Medical, Dental, Vision, and 401K offered through 3rd parties.

Ashley Distribution Services LTD

Regional OTR CDL-A Truck Driver | $81,000/year

Hiring in South Carolina and 46 other locations
OTR, Regional
Weekly
$81,000 Per year

Top 25% of drivers earn $81,000 annually. Regional routes. Regular 34-hour resets at home. No-touch freight.
Mix of live load/unload and drop and hook accounts. Consistent, high weekly miles. Excellent, premium equipment.
Generous benefits package: Can add up to an additional 27% on top of your base salary! Job stability.

A.N. Webber, Inc.

Regional CDL A Drivers | 50 CPM

Hiring in South Carolina and 2 other locations
Regional
Weekly
$0.50 Per mile

NO SLIP SEATING! Assigned late model Peterbilt 579’s.
BCBS medical with dental/vision and life options.
401k w/profit sharing. Direct deposit paid weekly.

Service Transportation, Inc.

Regional CDL A Truck Driver | 55 CPM

South Carolina
Regional
Weekly
$0.55 Per mile

401k with Company Match. Paid Vacation.
Orientation Completed in One Day!
No Touch Freight and Assigned Trucks.

Epes Transport System LLC

CDL A Regional Company Truck Driver | 53CPM

South Carolina
Regional
Weekly
$0.53 Per mile

Earn $.53 cpm. 65% drop & hook.
Home weekly. Insurance benefits - 30 days!
Full medical, dental and vision benefits.

Heartland Express

CDL-A Regional Truck Driver | Dry Van No Touch

Hiring in South Carolina and 46 other locations
Regional
Weekly
$67,000 - 94,000 Per year

$67,000 $94,000 depending on location.
Dry Van Freight No Touch, Drop and Hook.
Health, dental, vision and life insurance.

Epes Transport System LLC

Dedicated CDL A Driver | $1400/week

South Carolina
Regional
Weekly
$1,400 Per week

Full Benefit package - Dental/Health/401K and more.
EARN UP TO $1400 A WEEK.
Home weekends and throughout the week!!

Indianapolis Fruit Company

Reefer Truck Driver - CDLA - Indianapolis, IN

Hiring in South Carolina and 46 other locations
Regional
2 weeks out
$29 Per hour

401K with 4% company match available after 1-year of employment
Shifts typically start between 12am – 5am. Typical workday is 12-14 hour per day
Routes can have 3-10 stops per day

Central States Mfg.

Regional Flatbed CDL A - Claysburg

Hiring in South Carolina and 47 other locations
Regional
Weekly
$80,000 Per year

401(k) plan w/ 4% match
Annual 5% Profit-Sharing Bonus
Home EVERY weekend & paid holidays

Integrity Gas Services LLC

Regional or OTR Class A CDL Drivers

Hiring in South Carolina and 47 other locations
Regional
Flexible
$23 Per hour

Integrity Gas Services is looking for safe company drivers to run regional or OTR
Pay $23/hour with overtime paid at time and a half after 40 hours. $50 per day per diem
Weekly Settlements via ACH. 401k & 401k match. Profit sharing

KLM Trucking

CDL-A Truck Driver | No Touch | Dry Van

Hiring in South Carolina and 47 other locations
Regional
Weekly
$1,210 - 1,565 Per week

No touch freight. Regional operating area. Weekends off
Assigned manual tractors. Dry van trailers. Safety incentives available
Positions are limited. 6 months recent tractor trailer experience required.

Odysseia

CDL C Sprinter Van / Cargo VanOwner Operator

Hiring in South Carolina and 47 other locations
Regional
Weekly
$1,000 Per week

No authority; NO MC. Be ready to make long-distance/other loads; local - rarely and occasionally.
Own a Cargo van/Sprinter van (2010 and newer, NO rental vehicles).
Minimum inside dimensions of the cargo area 100x50x50 inches (L x W x H).

Pelts Xpress

CDL A Owner Operator | Regional Runs

Hiring in South Carolina and 46 other locations
OTR, Regional
Flexible
88% Of gross

Consistent direct customer freight, both Regional and OTR!
88% of gross revenue. Up to $0.40 fuel discount (100% to the owner)
Flexible dispatch adjusted to your preference. Solo & Team loads

FREE 30 Days Trailer Rent

Up to $0.40 fuel discount (100% to the owner)

Plates & Registration Program

Delta Carrier Group, Inc

CDL A OTR Lease Driver / SAP Accepted

Hiring in South Carolina and 47 other locations
OTR, Regional
2 weeks out
$2,500 Per week

Fuel discounts available!. Reefer average 2500-3000 Miles weekly.
No down payment OR balloon payment. Tons of new trucks available
Reefer truck Driver needs to have at least 1 year recent OTR experience

Regional CDL driver jobs in South Carolina